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|Rats roam around an arena (A) before tackling a maze memory task. A reward awaits them in the T-maze placed in the arena (B). While it sleeps, the rat consolidates the memory of where the reward was located (C). A place cell emits an action potential every time the rat is in one particular location in the arena (D). A dot is placed at each point a grid cell emits an action potential. The firing location of grid cells (see dots) form a grid over the arena (E). While the rat is asleep, grid cells replay this firing pattern (C). Credit: IST Austria|
“Until now, the entorhinal cortex has been considered subservient to the hippocampus in both memory formation and recall. But we show that the medial entorhinal cortex can replay the firing pattern associated with moving in a maze independent of the hippocampus. The entorhinal cortex could be a new system for memory formation that works in parallel to the hippocampus,” Jozsef Csicsvari explains.